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Time delay toxin activation : ウィキペディア英語版 | Time delay toxin activation
Time Delay Toxin Activation (TDTA) belongs to a class of chemotherapy drugs known as High Specificity Anticancer Agents. This is a process for manufacturing and administering chemotherapy drugs in a nontoxic, proto-drug form. Then, after a time delay to allow for concentration in the target cancer or invasive tissues or cells, the non-toxic drug is then modified by an activation drug to selectively provide toxic levels of a pharmacologically active agent to the target issue. This minimizes the toxicity to healthy cells, reducing the adverse side-effects of chemotherapy. This idea was first proposed by Dr. Evan Harris Walker in 1980. ==References==
* (【引用サイトリンク】url=http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040192578%22.PGNR.&OS=DN/20040192578&RS=DN/20040192578 ) * (【引用サイトリンク】work=USPTO Full text patent database )
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